The Bears also set an NFL record for the biggest comeback without scoring an offensive touchdown in league history.

[4] The postgame press conference was notable for Cardinals head coach Dennis Green's profanity-laced rant, highlighted by the quote "But they are who we thought they were!

Earlier in the year, in the preseason, the Cardinals defeated the Bears at Soldier Field 23–16 in a Friday night game.

The team was led by the talented-yet-inconsistent quarterback Rex Grossman, running back Thomas Jones, wide receiver Muhsin Muhammad, linemen John Tait, Olin Kreutz, and Roberto Garza, defensive linemen Adewale Ogunleye, rookie Mark Anderson, who eventually recorded 12 sacks on the season, linebackers Brian Urlacher, Lance Briggs, and Brendon Ayanbadejo, rookie and future Hall of Famer and record holder for career returns for touchdowns and punt return touchdowns Devin Hester, a cornerbacking tandem in Charles Tillman and former record holder for the longest play in NFL history (broken by San Diego Chargers cornerback Antonio Cromartie) Nathan Vasher, Chris Harris, Mike Brown, and the 7th most accurate kicker in NFL history in Robbie Gould.

The team's roster featured rookie quarterback and 2004 Heisman Trophy winner Matt Leinart, as well as rookie Leonard Pope, along with serious receiving threats in Anquan Boldin and Larry Fitzgerald, along with J. J. Arrington, running back Edgerrin James, Obafemi Ayanbadejo, brother of Brendon Ayanbadejo (both brothers played together with the Bears in the preseason in 2007), 3x Pro Bowler Darnell Dockett, Gerald Hayes, Orlando Huff, Calvin Pace, kicker Neil Rackers, as well as former MVP and Super Bowl XLIII quarterback Kurt Warner at backup.

In the second quarter, after exchanging punts, Grossman threw another interception, this time to Gerald Hayes.

Safety Mike Brown recovered the fumble and returned it 3 yards for a touchdown with just two seconds left in the quarter, making the score 23–10.

On the second play of the ensuing possession, Edgerrin James had the ball stripped by Brian Urlacher.

[12] The game also featured one of the best performances of Brian Urlacher's career, with 19 tackles and a forced fumble that was returned for a touchdown.

Teammate Devin Hester commented on Urlacher's performance, stating, "We watched the film and everybody was saying that he just turned into the Incredible Hulk the last four minutes of the game, just killing people and running over and tackling whoever had the ball.

After the loss, in the postgame press conference, Cardinals coach Dennis Green lost his temper, letting out a profane meltdown about the fact that the Cardinals defeated the Bears in the preseason, and because of that, they were confident in beating them again, and that his team blew it after attacking the Bears' weaknesses, and also yanked the podium, destabilizing the microphone before storming out of the room.

[16] The Bears finished the season with a 13–3 record, losing only to the Miami Dolphins, New England Patriots, and Green Bay Packers, and met Peyton Manning and the Indianapolis Colts in Super Bowl XLI but lost, 29–17.

The Cardinals ultimately dropped to 5–11 at the end of the season, and Dennis Green was fired and was replaced by Ken Whisenhunt.

[23][24] *Completions/Attempts aCarries bLongest play cReceptions dTackles eForced Fumbles fLongest field goal at University of Phoenix Stadium, Glendale, Arizona