The 2006 Columbia Lions football team was an American football team that represented Columbia University during the 2006 NCAA Division I FCS football season.

In their first season under head coach Norries Wilson, the Lions compiled a 5–5 record and were outscored 163 to 150.

Matt Barsamian, Adam Brekke and Uche Osadebe were the team captains.

[1] The Lions' 2–5 conference record placed them in a three-way tie for sixth in the Ivy League standings.

[2] Columbia played its homes games at Lawrence A. Wien Stadium in Upper Manhattan, in New York City.