Listed below are the dates and results for the 2006 FIFA World Cup qualification rounds for Africa.

51 teams took part (only Comoros and Djibouti did not enter), competing for 5 World Cup places.

Nine teams entered the competition directly in the second round: the five teams that qualified for the 2002 World Cup Finals (Cameroon, Nigeria, Senegal, South Africa, and Tunisia) and the four highest-ranking teams in the 25 June 2003 FIFA world rankings (Congo DR, Côte d'Ivoire, Egypt, and Morocco).

The African qualifying zone saw four out of five finals places going to World Cup debutants (Angola, Togo, Côte d'Ivoire and Ghana).

The African zone also featured a group of death — Group 3, which brought together Africa's most frequent World Cup qualifier Cameroon with the two eventual finalists of the 2006 Africa Cup of Nations: Egypt and the Ivory Coast.