Dale Earnhardt, Inc.'s Martin Truex Jr. finished second and Joe Gibbs Racing's Denny Hamlin was third.

Biffle took the lead from Riggs, only to lose it to J. J. Yeley during the pit stop rotation, before passing him with twelve laps remaining to win his second race of the season and eleventh of his career.

Denny Hamlin and Kevin Harvick tied for third and Dale Earnhardt Jr. completed the top five drivers competing for the 2006 Chase for the Nextel Cup.

[9] Johnson, the 2004 championship runner-up, had been second in points entering the past three races at Homestead, and stated his strategy was to finish ahead of his competitors.

"[10] Kenseth stated that his only chance of winning his second championship was if Johnson did not finish, and he was pessimistic given his recent poor performance, "He's going to have to have problems, and we're going to have to have a lot of good luck to get in there.

After leaving Formula One in July 2006, Juan Pablo Montoya partook in the Ford 400 for Chip Ganassi Racing in its No.

30 car as preparation for his full-time Nextel Cup Series debut for the 2007 season after team owner Chip Ganassi filed an additional entry for the event.

Burton, Biffle, Kahne, Brian Vickers, Ryan Newman, Martin, and Scott Riggs rounded out the session's top ten drivers.

[1] Morgan Shepherd withdrew from the race before qualifying because an accident in the first practice session caused irreparable structural damage to his car.

[19] Kyle Busch, Sadler, Burton, Vickers, Harvick, J. J. Yeley, David Gilliland, and Clint Bowyer completed the top ten starters.

[1] The twelve drivers who failed to qualify were Ward Burton, Brandon Whitt, Atwood, Kenny Wallace, Todd Kluever, David Ragan, Michael Waltrip, Mike Skinner, Derrike Cope, Kevin Lepage, Carl Long, and Chad Chaffin.

Burton, Scott Wimmer, Kyle Busch, Kahne, Bowyer, Vickers, and Johnson occupied positions four through ten.

[23] Live television coverage of the race began at 14:01 Eastern Standard Time (UTC+04:00) in the United States on NBC.

[26] The race commenced at 15:11 local time but one lap was deduced from its scheduled distance because NASCAR located debris on the track between the first and second corners.

[26] Two laps later, Kurt Busch made contact with the backstretch wall as he exited turn two,[25] ricocheted off it,[1] and Bobby Labonte collided with the rear of his car, resulting in the first caution.

Two laps later, the second caution was shown:[25] Kurt Busch lost control of his car after a flat tire caused him to strike the wall exiting turn four, littering debris.

[25] Montoya sustained a flat left front tire from made minor contact with Mears and Earnhardt on lap 22.

[25] Biffle passed Martin Truex Jr. for second 11 laps later, as Earnhardt pulled away from the rest of the field after repelling multiple challenges for the lead.

[1][25] Multiple drivers (including Earnhardt) entered pit road for tire changes and car adjustments during the caution.

Earnhardt had a slow stop because of a rear lug nut problem, and Truex led at the restart on lap 166.

[26] On lap 188, Robby Gordon crashed exiting turn four and spun 360 degrees as Johnson steered left to avoid hitting him, bringing out the seventh caution.

[1][25][26] Under the caution, multiple drivers (including Truex), made pit stops for tires and car adjustments.

[26] Mike Bliss' engine failed on lap 206, laying oil on the track and causing the eighth caution.

[26] Lap 247 had the ninth caution; Newman's left-rear tire was cut from contact with Montoya, and he slid through some grass on the backstretch.

[27] A tenth caution was displayed for three laps, until race officials showed a red flag for 7 minutes, 58 seconds for track cleanup as cars stopped on the turn three banking.

[2] He said the victory made up for his season struggles and praised his car for assisting him in winning, "It does a lot for us, Everybody knows this has been a tough year for us.

"[30] TTruex appreciated that his fast car allowed him to run strongly for most of the race, "It's been a pretty tough season.

"[36] After the race, NASCAR officials summoned Newman and his crew chief Matt Borland to meet with them about his accident with Montoya on lap 252 so that they could question the pair about whether the contact was intentional.

"[28] According to Newman, Montoya's car cut in front of his, "I felt bad for the situation because, obviously, it looked like I was retaliating, but that's not the case.

Harvick and Earnhardt were fourth and fifth with 6,397 and 6,328 points respectively, and Jeff Gordon, Burton, Kahne, Martin, and Kyle Busch rounded out the top ten drivers in the final Chase for the Nextel Cup standings.