Pre-game media coverage of the game focused on Louisville's loss of star quarterback Brian Brohm to injury, Virginia Tech's fall from being a contender for the national championship, the fact that both teams were playing under new conference affiliations, and the rise of Virginia Tech quarterback Marcus Vick, younger brother of NFL star Michael Vick.
Louisville led for much of the game, beginning with an 11-yard touchdown pass in the first quarter by backup quarterback Hunter Cantwell, who filled in for the injured Brohm.
[13] West Virginia later went on to finish 11–1 for the season, winning the Big East championship and defeating the Georgia Bulldogs in the 2006 Sugar Bowl.
[16] Unfortunately for the Cardinals, starting quarterback Brian Brohm, who had the sixth-best season (in terms of passing yards) in Louisville history, suffered a season-ending knee injury.
At North Carolina State, the Hokies trailed at halftime and were tied at the beginning of the fourth quarter before eking out a 20–16 win in the final minutes.
[27] Pregame media and fan interest surrounding the game focused largely on Louisville's top-ranked offense and Virginia Tech's first-ranked scoring defense.
[28] Other major points of media coverage included the two teams' quarterbacks: Louisville's Hunter Cantwell, who replaced starter Brian Brohm after Brohm suffered a season-ending knee injury; and Virginia Tech's Marcus Vick, brother of National Football League star Michael Vick.
Also a concern for Louisville was the health of star running back Michael Bush, who missed two games in November due to an injury.
[34] With star quarterback Brian Brohm having undergone surgery to repair a torn anterior cruciate ligament, there were some questions as to how backup Hunter Cantwell would perform under pressure.
[34] Cantwell played well in the Cardinals' season-ending contest against Connecticut, but some commentators predicted that Virginia Tech's quicker defense would pose problems for him.
[36] Running back Michael Bush was predicted to return to form after suffering a foot injury that kept him out of two games in November.
But with Brohm on the sidelines, it was expected the Cardinals would rely on Bush's legs more than usual, in an effort to minimize the need for the inexperienced Cantwell to pass the ball.
[37] Louisville wide receiver Mario Urrutia, who caught 31 passes for 702 yards and six touchdowns during the regular season,[38] stirred a bit of controversy in the final days leading up to the Gator Bowl after he declared that Virginia Tech's first-ranked defense was "mostly hype".
[32] Adding to the injury situation for Virginia Tech was offensive tackle Jimmy Martin, who suffered a sprained knee ligament in practice leading up to the game.
He was also named a second-team Associated Press All-American,[48] and he won the Dudley Award, given annually to the best college football player in the state of Virginia.
[51] Tech cornerback Jimmy F. Williams, considered a cornerstone of the Hokie defense, was a finalist for the Nagurski Trophy that season, but lost to Louisville's Elvis Dumervil.
[59] Virginia Tech won the ceremonial pre-game coin toss to select first possession and deferred its option to the second half; Louisville elected to receive the opening kick.
Smith surprised the Tech defense and broke free for a 30-yard run, converting the first down and continuing the Louisville drive.
Tech players committed three separate 15-yard personal fouls during the drive, one of which came after Louisville's successful extra point kick when cornerback Jimmy Williams bumped a game official.
After losing seven yards on the next play, Marcus Vick completed a 19-yard pass to tight end Jeff King, driving the Hokies into Louisville territory for the first time in the quarter.
Two plays later, Michael Bush broke free for a 34-yard run, driving Louisville deep into the Virginia Tech side of the field.
Though referees failed to observe the stomp, television commentators replayed the action, and Tech coaches considered pulling Vick from the game as punishment.
Still on his feet, Anderson quickly rushed the other way and, unimpeded, ran 39 yards into the end zone for a Virginia Tech touchdown.
The score and extra point energized Virginia Tech's offense and defense and gave the Hokies an 11-point lead—35–24—with 4:45 remaining in the game.
Louisville had one final chance on offense after a Tech punt, but three consecutive desperation Hail Mary passes were unsuccessful.
[69] Despite being more highly promoted in pregame media coverage, Virginia Tech quarterback Marcus Vick was outperformed statistically by Louisville's Hunter Cantwell.
Louisville's Kolby Smith carried the ball three times for 32 yards, including a 30-yard run that was the game's second-longest rushing play.
The game itself provided more than $14 million in economic benefit to the Jacksonville area as Louisville and Virginia Tech fans flocked to the region, spending money on food, hotel rooms, transportation, and entertainment.
[74] Following the 2005 ACC Championship Game, Virginia Tech quarterback Marcus Vick stormed off the field, refusing to talk to reporters following the loss.
The traffic stop, an earlier suspension from the team, and his unsportsmanlike conduct during the 2005 ACC Championship Game and 2006 Gator Bowl were used as grounds for his dismissal.