The 2006 Grand Prix of Road America was the twelfth round of the 2006 Bridgestone Presents the Champ Car World Series Powered by Ford season, held on September 24, 2006 at Road America in Elkhart Lake, Wisconsin.

Dan Clarke took the pole, the first and only of his Champ Car career.

A. J. Allmendinger won the race, his fifth and last win of the year and his Champ Car career.

The event is most remembered for a horrific crash involving Katherine Legge that resulted a 42-minute red flag.

The rear wing on her car failed just before the high speed Turn 11 Kink, the unexpected loss of downforce caused her to crash violently into the catch fence, demolishing the car.