The 2006 Lafayette Leopards football team represented Lafayette College in the 2006 NCAA Division I FCS football season.

The team was led by Frank Tavani, in his seventh season as head coach.

The Leopards played their home games at the renamed Fisher Field at Fisher Stadium in Easton, Pennsylvania.

All games were broadcast on the Lafayette Sports Network (LSN).

This college football 2000s season article is a stub.