The House session ending in January 2007 consists of 139 (87%) Democrats, and 21 (13%) Republicans.

Similarly, Republicans could not hope to gain the 59 seats needed to take control of the chamber, as there were not enough challengers to make that possible.

In the 4th Barnstable District, Sarah Peake (D-Provincetown) defeated Aaron Maloy (R-Orleans) to take the seat of retiring Shirley Gomes (R).

In the 13th Middlesex, incumbent Susan W. Pope (R-Wayland) was defeated by Thomas Conroy (D-Wayland).

No other incumbents were defeated, and all other open seats were retained by the party holding them.