The 2006 NCAA Division II women's basketball tournament was the 25th annual tournament hosted by the NCAA to determine the national champion of Division II women's collegiate basketball in the United States.

[1] Grand Valley State defeated American International in the championship game, 58–52, to claim the Lakers' first NCAA Division II national title.

For the second consecutive year, the championship rounds were contested at the Summit Arena in Hot Springs, Arkansas.

Location: Eddie King Gym Host: University of Charleston Location: Weiser Gymnasium Host: Drury University Location: Betty Engelstad Sioux Center Host: University of North Dakota Location: James W. Moore Fieldhouse Host: Southern Connecticut State University Location: Wells Center Host: Henderson State University Location: Spaulding Gym Host: Shaw University Location: Lee Arena Host: Washburn University Location: Sam Carver Gymnasium Host: Western Washington University Location: Summit Arena Hosts: Henderson State University and Hot Springs Convention Center