The 2006 NCAA Division I women's volleyball tournament began on November 30, 2006, with 64 teams and concluded on December 16, 2006, when top ranked Nebraska defeated second ranked Stanford 3 sets to 1 in Omaha, Nebraska for the program's third NCAA title.

Thirty-one conferences had an automatic berth to the 2006 NCAA Tournament, and the other 33 spots were filled by at-large bids.

Nebraska sophomore Jordan Larson was named the regional's most outstanding player, as she tallied a career high 21 kills in the dramatic comeback win.

Perhaps the biggest upset of the tournament occurred in the regional final, when defending champion Washington defeated third seed Penn State on UW's home floor in front of 6,000 fans.

Top seeded Nebraska was playing in front of an NCAA record 17,013 Husker fans in Omaha.

AVCA National Player of the Year Sarah Pavan served 10 straight points in one of the games and had 22 kills in the match.

In the second semifinal, second seeded Stanford completely dominated the match, knocking out defending national champion Washington.

Nebraska finished the season with a 33–1 record, with their only loss coming to Big 12 opponent Colorado in a five-game upset.