Half of the 100 seats in the Senate were up for election with the winning candidates serving six-year terms.

After the election, on 13 March 2006, Muhammad Mian Soomro of the ruling Pakistan Muslim League (Q) (PML(Q)) was re-elected to the position of Chairman with 58 votes, defeating Abdul Rahim Khan Mandokhel of the Pashtunkhwa Milli Awami Party (PMAP), who only received 39 votes.

On the same day, Jan Mohammad Jamali of the PML(Q) was elected to the position of Deputy Chairman with 59 votes, defeating Sajid Mir of the Pakistan Muslim League (N) (PML(N)), who only received 39 votes.

Jamali replaced Khalilur Rehman, also of the PML(Q).

Moreover, Wasim Sajjad of the PML(Q) continued serving as the Leader of the House, whereas Raza Rabbani of the Pakistan People's Party (PPP) continued serving as the Leader of the Opposition.