The men's 4 × 100 metre medley relay competition at the 2006 Pan Pacific Swimming Championships took place on August 20 at the Saanich Commonwealth Place.

[1][2] The last champion was the United States.

[3] Prior to this competition, the existing world and Pan Pacific records were as follows: All times are in minutes and seconds.

This event was a timed-final with two heats.

The final was held on August 20, at 20:40.