The 2006 PapaJohns.com Bowl was the inaugural postseason college football match of the game, between the South Florida Bulls and the East Carolina Pirates at Legion Field in Birmingham, Alabama.

The University of South Florida represented the Big East Conference and East Carolina University represented Conference USA.

Notably, South Florida had previously been a member of C-USA.

Moreover, East Carolina's then head coach Skip Holtz, would later become USF head coach Jim Leavitt's successor following the 2009 season.

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