The 2006 Southern Illinois Salukis football team represented Southern Illinois University as a member of the Gateway Football Conference during the 2006 NCAA Division I FCS football season.
They were led by sixth-year head coach Jerry Kill and played their home games at McAndrew Stadium in Carbondale, Illinois.
The team received an at-large bid to the FCS playoffs, where they defeated Tennessee–Martin before losing to Montana in the quarterfinals.
7 in The Sports Network's postseason ranking of FCS teams.
This college football 2000s season article is a stub.