Republican The 2006 Texas Senate election was held on Tuesday, November 7, 2006.

Incumbent Democratic Senator Ken Armbrister did not run for re-election.

No other Democrat ran to replace him, allowing Republican Glen Hegar to easily win the race, flipping the seat.

Incumbent Frank Madla was ousted by Uresti in contentious Democratic primary race.

[3] Thought to potentially add to the competitiveness of this Senate race was District 29's historically low-voter turnout and Republican "Dee" Margo's close connections to President George W. Bush via First Lady Laura Bush's close friendship to "Dee" Margo's spouse, El Pasoan Adair Margo.