The 2006 USA Indoor Track and Field Championships were held at the Reggie Lewis Track and Athletic Center in Boston, Massachusetts.

Organized by USA Track and Field (USATF), the two-day competition took place February 24–26 and served as the national championships in indoor track and field for the United States.

[1] The championships in combined track and field events were held at a different time.

[2][3] The meeting served as a qualifier for the U.S. team at the 2006 IAAF World Indoor Championships.

At the meeting, Terrence Trammell and Me'Lisa Barber set world leads in the men's 60 m hurdles and women's 60 m respectively.