In the Pennsylvania 6th congressional district election, incumbent Republican Jim Gerlach defeated Democratic opponent Lois Murphy by a 50.7%–49.3% margin to secure a third term.

[10] In the Pennsylvania 7th congressional district election, long-time incumbent Republican Curt Weldon was defeated by retired Navy 3-star admiral Joe Sestak.

Haverford Democrat Paul Scoles, who ran poorly funded race against Weldon in 2004, also backed out in early February, throwing his support behind Sestak.

The investigation focuses on the lobbying firm Solutions North America owned and run by daughter Karen Weldon and local Republican operative Charlie Sexton, which was hired for $1 million, and whether Weldon was involved in obtaining the contracts or was lobbied by his daughter's firm.

"[4] Larry Sabato's Crystal Ball, in late June, rated as one of the top thirty most competitive House races in the nation.

Sabato has said that "Weldon has deep roots in this district, but his persistence on the issue of finding weapons of mass destruction in Iraq has struck more than several observers as unusual.

Republican four-term incumbent Don Sherwood was defeated by Democrat Chris Carney, a former Defense Department consultant and Navy lieutenant commander.

CQPolitics noted that "[a]t the outset of the 2006 midterm campaign cycle, it would have been difficult to identify a more politically 'safe' member than Pennsylvania Rep. Don Sherwood.

"[23] But, he "enters the general election campaign in a weakened position mostly because of his extramarital relationship with a young woman, to which he publicly admitted last year.

Carol Sherwood, the Congressman's wife, wrote a letter to registered Republicans in the 10th District in which she lambasted Carney as someone who "gets some pleasure out of hurting our family" and stated that "I am certainly not condoning the mistake Don made, but I am not going to dwell on either."

Bush supported Sherwood as "the right man to represent this district", to which the President drew uncertain applause from the audience, which included several empty tables.

Many voters also resonated with Carney's vague yet inspiring vow "to make Pennsylvania proud", a slogan that became very familiar to the 10th District, as well as his impressive record as a senior terrorism advisor in the Pentagon and his Navy service.