The 2007–08 Czech First League, known as the Gambrinus liga for sponsorship reasons, was the fifteenth season of Czech Republic's top-tier of football.
The season started on 4 August 2007 and concluded on 17 May 2008.
Příbram and Slovácko were relegated to the second division after finishing last and second to last, respectively, in the 2006–07 season.
Viktoria Žižkov (as champions) and Bohemians 1905 (as runners-up) were promoted from the second division.