The 2007–08 European Challenge Cup pool stage was the opening stage of the 12th season of the European Challenge Cup, the second-tier competition for European rugby union clubs.

It began on 8 November 2007 when Sale Sharks hosted Montpellier and ended with the Newcastle Falcons / El Salvador game on 20 January 2008.

The five pool winners and the best three runners-up advanced to the knockout stage.

These teams then competed in a single-elimination tournament that ended with the final at Kingsholm Stadium in Gloucester on 25 May 2008.

All times are local to the game location.