Vardar were the defending champions, having won their fifth title.
The 2007–08 champions were Rabotnichki Kometal who won their first title.
The draw was held on 5 September 2007 in Skopje.
The draw was held on 17 October 2007 in Skopje.
The first legs were played on 23 and 24 October and second on 6 and 7 November 2007.