The first round of the 2007–08 UEFA Cup began on 20 September 2007, which narrowed clubs down to 40 teams in preparation for the group stage.
[4] Notes The draw, which was conducted by UEFA General Secretary David Taylor and Gérard Houllier, the winning coach in the 2000–01 tournament, was held on Friday, 31 August 2007 at 13:00 CET in Monaco.
Zenit Saint Petersburg won 4–1 on aggregate.
2–2 on aggregate; IF Elfsborg won on away goals.
3–3 on aggregate; Dinamo Zagreb won on away goals.
0–0 on aggregate; Sparta Prague won 4–3 on penalties.
Red Star Belgrade won 2–0 on aggregate.
Hapoel Tel Aviv won 1–0 on aggregate.
1–1 on aggregate; Mladá Boleslav won 4–2 on penalties.