The knockout stage of the 2007–08 UEFA Cup began on 13 February 2008.
The team that has the higher aggregate score over the two legs will progress to the next round.
If away goals are equal too, 30 minutes of extra time are played, followed by a penalty shoot-out if scores are still level.
In the final, the tie is played over just one leg at a neutral venue.
If scores are level at the end of normal time in the final, extra time is played, followed by penalties if scores remain tied.
Russian club Zenit Saint Petersburg won the final 2–0 against Scottish side Rangers, with goals from Igor Denisov and Konstantin Zyryanov coming in the last 20 minutes of the game to give Zenit their first UEFA Cup title.
The draw for the round of 32, which was conducted by UEFA General Secretary David Taylor and Michele Centenaro, UEFA's head of club competitions, was held on Friday, 21 December 2007 at 13:00 CET in Nyon, Switzerland.
2–2 on aggregate; Zenit Saint Petersburg won on away goals.
The draw for the round of 16, which was conducted by UEFA General Secretary David Taylor, was also held on Friday, 21 December 2007 at 13:00 CET in Nyon, Switzerland.
3–3 on aggregate; Zenit Saint Petersburg won on away goals.
The draw for the quarter-finals, semi-finals and final, which was conducted by UEFA General Secretary David Taylor and Denis Law, the ambassador for the final in Manchester, was held on Friday, 14 March 2008 at 14:00 CET in Nyon, Switzerland.