The 2007–08 Guinness Premiership was the 21st season of the top flight of the English domestic rugby union competitions, played between September 2007 and May 2008.

Due to the 2007 Rugby World Cup the season started a week later than usual, as England were trying to defend their title.

During the course of the season, London Wasps went from 10th in the league during October, to beat Leicester in the Guinness Premiership Final at Twickenham on 31 May 2008.

Leeds Carnegie, having won the 2006–07 National Division One, replaced Northampton Saints, who were relegated last season after finishing bottom of the table.

Note: Flags to the left of player names indicate national team as has been defined under World Rugby eligibility rules, or primary nationality for players who did not earn international senior caps.