Conference foe Vanderbilt returned to the schedule while non-conference opponents South Florida and Tennessee Tech played the Tigers for the first time.

Cox was joined in the backfield by a stable of talented backs including Brad Lester, Ben Tate and freshman Mario Fannin.

Prior to the season, a new $2.9 million, 30-foot-high (9.1 m), 74-foot-wide (23 m) high-definition(HD) Daktronics LED video display was installed in the south end-zone of Jordan–Hare Stadium.

[4] Auburn was ranked #14 in the initial USA Today Coaches Poll, a component of the Bowl Championship Series, released on August 3, 2007.

[24] The road schedule with all four opponents finishing in the Top 25 in 2006 including the defending BCS champion Florida Gators, was ranked as the 2nd toughest.

*Entering season Brandon Cox threw a three-yard touchdown pass to tight end Gabe McKenzie with 2:01 remaining in the fourth quarter, then Antonio Coleman returned a recovered fumble 34 yards 50 seconds later for another touchdown and Auburn defeated Kansas State in the season opener for both teams.

Auburn had won the only two previous meetings with Kansas State in 1978 and 1979,[1] and continued that tradition with a tough win in the home opener against the Wildcats.

Quarterback Matt Grothe threw a 14-yard touchdown pass to receiver Jesse Hester in overtime to lead USF to a 26–23 upset win over Auburn.

The Tigers committed five turnovers-three lost fumbles and two passes thrown for interceptions-as the Bulls won their first-ever game against a team from the Southeastern Conference.

In a game that would see the Tigers turn the ball over five times, and their starting quarterback benched in favor of a true freshman, Auburn fell to the Bulldogs despite outgaining them by 110 yards.

Auburn wore all-white uniforms at home for this game and removed the traditional AU logo from their helmets to honor the 50th anniversary of the 1957 National Championship team.

[36] For the second time in three weeks, freshman kicker Wes Byrum kicked the winning field goal in the final minute of play as the 22nd-ranked Tigers defeated the Razorbacks 9–7.

Byrum's three field goals accounted for all nine of Auburn's points as the Tigers won their fourth consecutive game and avenged a 27–10 loss to the Razorbacks in 2006 at Jordan–Hare Stadium.

The Tigers suffered a 20+ loss for the second straight year but Auburn still leads the series in Athens 18–10 and has won 10 of the last 13 matchups in Sanford Stadium.

Following the close of the regular season, head coach Tommy Tuberville was offered a two-year contract extension that was verbally accepted on December 4, 2007.