The Reds failed on a bid to win the National League Central, falling out of serious contention by midseason and finishing in fifth place with a 72–90 record.
It was the second managerial change of the day, following the resignation of Seattle Mariners skipper Mike Hargrove.
The Reds won Mackanin's first game at the helm, 7–3 over the San Francisco Giants on the strength of a grand slam by Brandon Phillips.
The season also included highlights such as the Reds 2004 first-round draft pick, right-handed starting pitcher Homer Bailey making his MLB debut against the Indians on June 8.
Infielders Outfielders Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.