The team was coached by Gary Pinkel and played their home games at Faurot Field at Memorial Stadium.

The team was led by junior quarterback Chase Daniel, a Heisman Trophy candidate[1][2][3][4] who finished fourth in voting behind Tim Tebow, Darren McFadden, and Colt Brennan.

After losing the Big 12 Championship game 38–17 to the Sooners, Missouri was chosen to play Arkansas in the Cotton Bowl Classic in Dallas, in which the Tigers prevailed 38–7 to complete their 12–2 season.

Senior tight end Martin Rucker and freshman wide receiver Jeremy Maclin (as an all-purpose player) were named as first team selections, while junior quarterback Chase Daniel and junior safety William Moore were named to the second team.

[7] The Anderson & Hester rankings listed the team as National Champions, however the school does not claim the title.