This was the first Tournament since 2003 that regional sites were designated as "East", "West", "South", and "Midwest", rather than by the names of the host cities.

The automatic bid of the Ivy League, which did not conduct a post-season tournament, went to its regular season champion, Penn.

Winthrop's highly touted offense built a 21-point second-half lead before surviving a late Notre Dame rally to win, 74–64, earning their first tournament victory in school history.

The highest score accumulated by a team in the 2007 tournament went to Tennessee's 121 points over Long Beach State (South Regional), which set a school record.

Ohio State's Ron Lewis hit a three-pointer with two seconds remaining to force overtime against Xavier, and Pittsburgh fought Virginia Commonwealth's comeback from 19 points down to come up with the victory.

In the South Region, #2 Memphis barely defeated #3 Texas A&M as Aggie senior Acie Law, after a solid performance for most of the game, missed an open layup with under a minute left.

[8] #1 Ohio State sneaked past #5 Tennessee, coming back from 20 points down to win, 85–84, with a blocked shot by Buckeye Greg Oden with 0.2 seconds left.

In the East Region, #2 Georgetown won possibly the most controversial game of the tournament, beating #6 Vanderbilt, 66–65, on a shot by Jeff Green with 2.5 seconds left.

The play was controversial as Green appeared to travel, despite fans and analysts claiming it was a clean drop step.

Although Ohio State star freshman Greg Oden got into early foul trouble, a close game at the half turned into a blowout as the Buckeyes went on a 20–8 run to win.

[12][13] After a tight first-half, the Bruins slowly put away the top-seeded Jayhawks in the second-half using their 2006 national championship game experience, along with a strong defense.

[14] North Carolina led for most of the game and the entire second half, but Georgetown rallied from ten points down with six minutes remaining to force overtime.

In what was actually a close game for most of regulation, Florida's three-point shots, along with a 20–9 run in the second half, amounted to a Gator win.

A rematch of a regular season meeting, won 86–60 by Florida in Gainesville, The Gators survived 25 points and 12 rebounds from Buckeyes center Greg Oden with stellar play from guards Lee Humphrey and Taurean Green with inside contributions coming from Al Horford (18 points) and tourney Most Outstanding Player Corey Brewer.

This was also the first time in NCAA D-I men's basketball history that exactly the same starting five were able to win back-to-back titles (Joakim Noah, Corey Brewer, Lee Humphrey, Al Horford, Taurean Green).

Florida's Lee Humphrey also set the all-time NCAA Tournament record for three-point field goals made with 47.

Nantz was in a stretch in which he would broadcast Super Bowl XLI, the Final Four, and The Masters golf tournament all in a 10-week period.

[17] The complete list of announcing teams follows: Greg Gumbel once again served as the studio host, joined by analysts Clark Kellogg and Seth Davis.

Those games served as the first-ever live tourney telecasts on CSTV, which also provided a highlights show after each day of competition.

Kevin Harlan once again served as the play-by-play man at the Final Four with Bill Raftery and John Thompson on color.

[17] During the first- and second-round games in New Orleans, as part of the continuing recovery process from Hurricane Katrina, the NCAA allowed an additional floor decal recognizing the work of Habitat for Humanity's Collegiate Challenge and the NCAA Home Team program through the subregional's host institution, Tulane University.

In addition, Tulane student athletes and athletic department personnel built a new house, valued at $75,000 (US), which was paid for by the NCAA and their corporate partner Lowe's, on Girod Street between the New Orleans Arena, site of the games, and the Louisiana Superdome, which has hosted four Final Fours.