Toronto FC began play in Major League Soccer in 2007, and the club's first regular season match was on April 7, 2007, at the Home Depot Center in Los Angeles away to Chivas USA.

Danny Dichio scored the first goal ever for Toronto FC on May 12, 2007, in the 24th minute against Chicago Fire in the franchise's first ever win, a 3–1 victory.

[citation needed] Dichio was also the first ever Toronto FC player red-carded, being ejected in the 44th minute of the same game as his historic goal.

On September 22, Toronto FC ended their streak, scoring at the two-minute mark of their match against the Columbus Crew on a goal by Miguel Cañizalez, setting a league record at 824 minutes.

In their inaugural season, Toronto FC's average attendance was 20,130, the third highest in the league behind Los Angeles Galaxy (24,252) and D.C. United (20,967).