The 2008 AFC Cup was the fifth edition of the AFC Cup, played by clubs from nations who are members of the Asian Football Confederation.

20 clubs competed, including champions of the national leagues and champions of the primary knock-out competition from the following countries which are AFC-affiliated countries and which fall into the AFC's 'developing nations' category.

In that season, the clubs of Bangladesh, Turkmenistan, Indonesia did not participate.

Kitchee (2006–07 Hong Kong First Division League runners-up) East Bengal (2007 Indian Federation Cup winners) New Radiant (2007 Maldives FA Cup winners) Perak (2006–07 Super League Malaysia runners-up) Home United (2007 S.League runners-up) Al-Najma (2007 Bahraini King's Cup winners) Shabab Al-Ordon (2007 AFC Cup winners & 2006–07 Jordan FA Cup winners) Safa (2006–07 Lebanese Premier League runners-up) Sur (2007 Sultan Qaboos Cup winners) Al-Sha'ab Hadramaut (2006 Yemeni President Cup winners) The draw was held on 17 October 2007 in Kuala Lumpur, Malaysia.

The first and second legs of the final were played on 31 October and 7 November 2008, respectively.