President of Baseball Operations Andy MacPhail continued the rebuilding process.

The Baltimore Orioles posted a record of 68–93 and finished in last place in the AL East for the first time since the 1988 season.

Closer Chris Ray missed the entire season after Tommy John surgery, and so did his replacement Danys Báez.

Left-hander George Sherrill, acquired from the Mariners, was named the team's closer for the 2008 season and became the lone representative for the 2008 Major League Baseball All-Star Game, while Jeremy Guthrie was the Opening Day starter after an impressive rookie season and several solid spring training outings.

Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.