Al Ahly of Egypt defeated Coton Sport of Cameroon in the final to win their sixth title.

The preliminary round first legs were played on 15–17 February, and the second legs were played on 29 February-2 March 2008.4 Byes: ASEC Mimosas, Etoile du Sahel, JS Kabylie, Al Ittihad, Al Ahly, and Al Hilal.

2 CAF ordered that the tie was to be played over one leg in Kinshasa due to the civil war in Chad, but Renaissance FC objected to the ruling and refused to travel; they were ejected from the competition, fined $4000 and banned from CAF competitions for three years.

3 Tusker FC were ejected from the competition and fined $5000 after Kenyan immigration officials refused the appointed match officials for the first leg entry into the country.

Note: Clubs from the Central African Republic, Djibouti, Kenya, Liberia, Malawi, São Tomé and Príncipe, Sierra Leone and Somalia all had their entries rejected for failure to fulfil their financial obligations.