The 2008 Coca-Cola 600, the 49th running of the event, was a NASCAR stock car race held on May 25, 2008, at Lowe's Motor Speedway in Concord, North Carolina.

The Coca-Cola 600 was the twelfth scheduled stock car race of the 2008 NASCAR Sprint Cup Series, out of 36, and the 49th iteration of the event.

The complex features a 1.5 miles (2.4 km) quad-oval track that hosts NASCAR racing including the prestigious Coca-Cola 600 on Memorial Day weekend, the Nextel All-Star Challenge, and the Bank of America 500.

Both teams were also charged a US $100,000 fine in addition to having their crew chiefs suspended for the next six races starting at Dover and running through Daytona.

[8] The second practice session took place on Saturday, May 24, 2008, with Greg Biffle taking the top position with a speed of 180.282 mph.

[11] He began on P-1 with Sprint All-Star Race XXIV champion Kasey Kahne next to him filling out the front row.

Kasey Kahne, Jimmie Johnson, Tony Stewart, and Busch then traded the lead amongst themselves several times after Vickers fell out of contention.

Robby Gordon and Patrick Carpentier also had engine trouble, and Paul Menard was eliminated from the running due to his car overheating.

[3] After pit stops cycled through with 10 laps to go, Tony Stewart led the 2nd place car of Kasey Kahne by a large margin.