The 2008 Estoril Open was a tennis tournament played on outdoor clay courts.

4, Miami Masters winner and 2003 Estoril titlist Nikolay Davydenko, and Rotterdam semifinalist Ivo Karlović.

Other seeded players were Australian Open quarterfinalist and Adelaide runner-up Jarkko Nieminen, Rotterdam semifinalist Gilles Simon, Nicolas Mahut, Marc Gicquel and Michael Berrer.

The women's draw was headlined by Viña del Mar and Acapulco champion Flavia Pennetta, Auckland quarterfinalist Maria Kirilenko, and Antwerp runner-up Karin Knapp.

Also present in the field were 2005 Estoril titlist Lucie Šafářová, 2000 Estoril semifinalist Tathiana Garbin, Klára Zakopalová, Sofia Arvidsson and Camille Pin.