The 2008 La Serena Open was a men's tennis tournament played on outdoor clay courts.

The highlight of the tournament was the presence of Argentinian Mariano Puerta, former French Open runner-up in 2005, who returned to tennis in June 2007 after a 2-year ban due to doping.

A temporary court with a capacity of 1,500 was specially built for the tournament.

The following players received wildcards into the singles main draw:[2] The following players received entry from the qualifying draw: The following player received entry as lucky loser: Before the tournament 1 Rankings as of 7 January 2008.

The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: Before the tournament It was the 5th Challenger title for Ramírez Hidalgo in his singles career.