Jon Lester out-dueled John Lackey in Game 1 as the Red Sox prevailed by a 4–1 score.

When the series shifted to Boston for Game 3, the Angels narrowly prevailed after a twelve-inning duel thanks to a solo home run from Mike Napoli.

In their postseason debut, the Rays defeated the White Sox in four games to advance to the ALCS for the first time in franchise history.

Scott Kazmir and the Rays' bullpen would lead Tampa to victory in Game 2 by a 6–2 score despite the White Sox loading the bases in the top of the first.

When the series shifted to Chicago, the White Sox would get on the board with a 5–3 victory as Bobby Jenks held off a late rally by the Rays.

In Game 1, the Cubs jumped out to an early 2–0 lead, but it would be gone as James Loney hit a grand slam that put the Dodgers ahead for good as they won 7–2.

However, the Phillies would prevail in Game 4, as they jumped out to a 5–0 lead early and held on to win 6–2 to advance to the NLCS for the first time in 15 years.

The Brewers would return to the postseason again in 2011, where they defeated the Arizona Diamondbacks in five games in the NLDS before falling in the NLCS to the St. Louis Cardinals.

Daisuke Matsuzaka pitched eight solid innings as the Red Sox shut out the Rays 2–0 in Game 1 on the road.

In Game 5, the Rays looked poised to close out the series with yet another blowout win as they lead 7–0 going into the bottom of the seventh.

However, the Red Sox pulled off an improbable rally to win 8–7 and send the series back to Tampa.

Despite taking an early lead, the Rays put up three unanswered runs as they won 3–1 to secure their first ever AL pennant.

The Red Sox would return to the ALCS in 2013, where they defeated the Detroit Tigers in six games en route to a World Series title.

Game 2 was an offensive duel in which the Phillies' bullpen held off a rally by the Dodgers to go up 2–0 in the series headed to Los Angeles.

Game 3 was marred by controversy, as a dramatic benches-clearing incident in the third inning occurred when Dodgers starter Hiroki Kuroda threw a fastball over the head of the Phillies' Shane Victorino.

In Game 2, David Price held off a late rally by the Phillies to help the Rays even the series headed to Philadelphia.

The Phillies returned to the World Series the very next year in hopes of defending their title, but fell to the New York Yankees in six games.

TBS primarily aired all Division Series games, with sister network TNT used as an overflow channel.