Andy Murray defeated Gilles Simon in the final, 6–4, 7–6(8–6) to win the singles tennis title at the 2008 Madrid Open.

It was his second Masters title.

[1][2][3] David Nalbandian was the defending champion, but lost in the third round to Juan Martín del Potro.

[4][5] This was the last edition of the tournament to be held on indoor hard courts, as it would switch to outdoor clay courts the following year.

All seeds receive a bye into the second round.