In the Greensboro and Oklahoma City Regionals, the top seeds Connecticut and Tennessee won respectively to head to the Final Four.

Tennessee' Candace Parker was injured in the game against Texas A&M and had to leave twice, and be fitted with a sleeve to stabilize her shoulder.

In the New Orleans Regional, LSU beat North Carolina to reach the Final Four for the fifth consecutive time, tying a record set by Connecticut between 2000 and 2004.

Connecticut cut a Stanford lead to a single point, 47–46 when Candice Wiggins hit two three-pointers to start a 10–0 run.

Wiggins would go on to score 25 points in the game and would be named the Women's Basketball Coaches Association national player of the year.

Tennessee inbounded the ball to Candace Parker who passed it inside to Nicky Anosike, but her shot was deflected to Alexis Hornbuckle, who had missed seven of her field goal attempts.

[5] Once again, the system was the same as the Division I men's basketball tournament, with the exception that only 64 teams received bids, and there was no play-in game.

[1] USF and the Tampa Bay Times Forum also hosted a first and second round Men's Tournament subregional on March 21 and 23.

Also, akin to the men's tournament, at the regional sites, the NCAA installed floors that were custom made for the first time.

Because Cornell, Dartmouth, and Harvard finished in a tie for first place, Ivy League rules called for a two-game stepladder playoff.