Led by Mike Bellotti in his 14th and final season as head coach, the Ducks compiled an overall record of 10–3 with a mark of 7–2 in conference play, tying for second place in the Pac-10.

February 2 – Gary Zimmerman, offensive lineman for the Oregon Ducks from 1980 to 1983, was voted into the Pro Football Hall of Fame in Canton, Ohio.

Two other players were signed as free agents, Cameron Colvin with the San Francisco 49ers and David Faaeteete with the Chicago Bears.

Also, Jairus Byrd, Patrick Chung and Walter Thurmond III were named to the Chuck Bednarik Award watch list.

[8] July 7 – Jairus Byrd, Patrick Chung, and Walter Thurmond III named to the Jim Thorpe Award pre-season watch list.

[9] July 13 – While swimming in the McKenzie River with some of his teammates, redshirt freshman defensive back Todd Doxey drowned.

The accident occurred around 3:15 in the afternoon near the Marcola Road Bridge and he was pronounced dead at Sacred Heart Medical Center at 8:06 p.m.[10] July 26 – Junior linebacker Kevin Garrett was suspended indefinitely for a violation of team rules.

[12] August 18 – Senior Nick Reed has been named to the Walter Camp Football Foundation Player of the Year award list.

[13] August 25 – It was announced by GoDucks.com that sophomore quarterback Nate Costa had re-injured his left knee during a practice on the preceding Wednesday.

Current estimates place his recovery at eight to ten weeks, however the status of his ACL and MCL will be determined at the time of his surgery.

This win also marks the first time in the Oregon-Washington series, dating back to 1900, that Oregon has won 5 consecutive games against the Huskies.

However during Oregon's first possession, running back Jeremiah Johnson separated his shoulder and Roper threw his second interception of the season.

On the Ducks' possession of the overtime Chris Harper, Jeremiah Johnson and LeGarrette Blount all took turns running Oregon into the end zone for the game-winning touchdown.

During the Oregon possession of the first overtime, quarterback Justin Roper suffered a sprained knee and is currently expected to be out for two to four weeks.

Oregon's Jeremiah Johnson scored what would be the only touchdown given up by USC at home for the entire 2008 season The Ducks lost 16–0 last year in Los Angeles.

Oregon faced an unranked Cal team on the road during a rainy day in Berkeley with Kevin Riley as the starter.

Oregon capitalized on an interception at midfield on Cal's first possession with a 17-yard run by Jeremiah Masoli with the PAT missing.

[27] The Bears held the Ducks and got a safety when Oregon snapped the ball high and into the end zone on a punt attempt.

Cal took advantage of the free kick to advance down the field, during which Riley sustained a concussion when he failed to slide while attempting to gain a first down and was sandwiched between three defenders.

The only score of the quarter was set up by a 50-yard interception return by Worrell Williams, capped off by a 2-yard pass from Longshore to Nyan Boateng.

[27] In the fourth quarter, Ducks cornerback Jairus Bryd fumbled a punt which was recovered by the Bears, allowing Vereen to score on a 2-yard run to put the game away.

Oregon jumped out to a 17–3 early lead and led 20–17 at the half on a rain soaked field in Autzen Stadium.

However, a 40-yard touchdown hit from Masoli to LeGarrette Blounte sealed the Ducks win, 55–45, to avenge a loss to the Wildcats from last year.

Beavers won at Oregon for the first time since 1993 last year, ending a ten-year run of the home team winning in the series.

The stakes for this game were recently raised – if the Ducks win, they will place second in the PAC-10 and will more than likely receive a Holiday Bowl berth.

This will be Oklahoma State's second Holiday Bowl and first since 1988, when their current head coach Mike Gundy started at quarterback and that year's Heisman Trophy winner Barry Sanders lined up in the backfield.