The Roughriders attempted to repeat as Grey Cup champions, but, due to an abundance of injuries, lost to the BC Lions in the West Semi-Final game.

[2] Last season's starting quarterback Kerry Joseph was traded to the Toronto Argonauts on March 5, 2008, along with a third round pick in the 2010 CFL Draft in exchange for offensive tackle Glenn January, defensive lineman Ronald Flemons, the Argos' first-round pick in the 2008 CFL Draft and a 2010 second-round selection.

[5] The incident occurred on the night when the Roughriders were honouring past CFL legend Ron Lancaster, who recently died at the age of 69.

The club subsequently announced that in order to reduce the probability of a similar incident beer in the east stands (where the visitors bench is) would be sold in plastic cups for at least the remainder of the season.

[9] Running backs Wide receivers Slotbacks Defensive linemen Defensive backs Special teams Developmental squad Injured lists Suspended List Italics indicate Import player Roster updated 2008-10-30 Depth Chart • Transactions 46 Active, 11 Inactive, 7 PS → More rosters [10] [11] [12] [13] [14] Date and time: Saturday, November 8, 3:30 PM Central Standard TimeVenue: Mosaic Stadium at Taylor Field, Regina, Saskatchewan