The 2008 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2008 NCAA Division I FBS football season.

The Golden Eagles were led by first-year head coach Larry Fedora and played their home games at M. M. Roberts Stadium.

They are a member of the East Division of Conference USA.

They were invited to the New Orleans Bowl where they defeated Troy, 30–27.

This college football 2000s season article is a stub.