Following protracted disagreement between the organisers of the Grand Tours (ASO, RCS and Unipublic) and the UCI, all races organized by ASO, RCS and Unipublic were withdrawn from the ProTour calendar.

This removed all three Grand Tours (Giro d'Italia, Tour de France and Vuelta a España), four of the five monuments (Milan–San Remo, Paris–Roubaix, Liège–Bastogne–Liège and Giro di Lombardia) and four further races (Paris–Nice, Tirreno–Adriatico, La Flèche Wallonne and Paris–Tours).

Postal Service ceased operations at the end of the 2007 season.

Johan Bruyneel signed on to become the directeur sportif and revamp the embattled Astana; joining him are 2007 Tour de France champion Alberto Contador and 2007 Tour of California champion Levi Leipheimer.

Other major signings included American George Hincapie moving to Team High Road and Daniele Bennati from Lampre to Liquigas, while Giro d'Italia winner Danilo Di Luca left Liguigas for the UCI Professional Continental team LPR Brakes–Ballan.