Serena Williams defeated Jelena Janković in the final, 6–4, 7–5 to win the women's singles tennis title at the 2008 US Open.

This was also her second US Open (and third major overall) won without losing a set during the tournament.

1 Lindsay Davenport, who was defeated by Marion Bartoli in the third round.

1 Ana Ivanovic in the second round, making her the lowest-ranked player ever to defeat an incumbent world No.

[citation needed] Click on the seed number of a player to go to their draw section.