It was an impressive display of ticket-splitting by Delaware voters, as Castle, a Republican, obtained over 60% of the vote, while the Democratic candidates in the concurrent presidential, Senate, and gubernatorial elections all received over 60% of the vote as well.

[3] Three Democrats were on the primary ballot: children's rights advocate and 2006 independent candidate Karen Hartley-Nagle, veterinarian and Vietnam War veteran Jerry Northington, and Michael Miller.

In the general election, Republican incumbent Mike Castle was challenged by Democratic nominee Karen Hartley-Nagle and Libertarian Party candidate Mark Anthony Parks.

CQ Politics forecasted the race in Delaware's at-large congressional district as 'Safe Republican'.

Castle enjoyed a lead throughout the campaign, and ultimately won the election with slightly over 61 percent of the votes cast.