In the general election, the incumbent Democrat Shelley Berkley defeated Republican Kenneth Wegner, a Gulf War veteran and part-time Bail Enforcement Agent.

Heller had previously defeated Derby in the 2006 election, although this time the margin of victory was 10.4%, as opposed to just 5% two years before.

Incumbent Republican Jon Porter of Boulder City (campaign website) was considered to be at risk due to the increasingly Democratic electorate in the 3rd District.

Porter lost re-election to the Democratic nominee, Nevada Senate Minority Leader Dina Titus of Las Vegas (campaign website).

Leading Democratic candidates included Fraud Examiner Andrew Martin and Clark County prosecutor Robert Daskas, but Daskas dropped out in late April, citing family concerns.