Incumbent Republican Congressman Henry E. Brown, Jr. defeated Democratic candidate Linda Ketner by a surprisingly thin margin to win a fifth term in Congress.

Incumbent Republican Congressman Joe Wilson defeated Democrat and Iraq War Veteran Rob Miller by the thinnest margin of his electoral career.

Miller's performance in this conservative district rooted in eastern and southern South Carolina was surprising, though ultimately was not strong enough to unseat Wilson in his bid for a fifth term.

Long-serving incumbent Democratic Congressman John Spratt has been able to maintain popularity in this conservative district based in northern South Carolina, enabling to repeatedly win re-election despite the national mood.

This year proved no different, with Spratt easily winning a fourteenth term over Republican challenger Albert Spencer and Constitution Party candidate Frank Waggoner.