Major signings for the 2008 season are former Dragons halfback Mathew Head, backrower Corey Payne, and back Nick Youngquest.
Benji Marshall was injured in the third minute of round 1 with a knee ligament tear, sidelining him for eight to ten weeks.
After a four game losing streak, the Wests Tigers ended the South Sydney Rabbitohs' run of five-straight wins, beating them 36–12 in round 19.
In the final match of the season, the Wests Tigers farewelled captain Brett Hodgson with a win over the Gold Coast Titans at Robina.
Players leaving the club at the end of the season include Brett Hodgson, Ryan O'Hara, Ben Te'o and Stuart Flanagan.