The Huskies were a member of the Big East Conference and won their seventh NCAA championship against Stanford on April 6, 2010.

The team added one freshman, Kelly Faris, and Caroline Doty returned to the line-up after missing most of the prior season due to injury.

[17] After the WBCA Classic, UConn would play Vermont in a rematch of the previous year's NCAA opening round game.

UConn won easily 84–42, on a night in which senior Tina Charles became the second leading rebounder in school history.

However, after trading baskets early in the second half, UConn pulled out to a 22-point lead (74–52) with five minutes left in the game,[23] and coasted to their 49th consecutive victory, all of which were won with a double-digit margin.

The game was relatively close at halftime, 41–35, but UConn's Tina Charles scored 16 of her 24 points in the second half to help ensure a victory.

Tina Charles scored 25 points in the first half, single-handedly outscoring the entire UNC team.

Midway through the first half, it appeared UConn was heading for another easy win, as they had doubled the Sooners score 24–12.

However, Oklahoma brought the game back to a two-point margin at halftime, and took a one-point lead in the second half.

The four teams participating in the three-day round robin event were host UConn, Hofstra, Richmond, and Clemson.

The result was never in doubt, as UConn won 91–24, their largest margin over a Big East team in seven years.

UConn started out with an 18–2 run, but Charles and Moore got into early foul trouble, and had to sit on the bench.

The announcers were unsure of the reason at the time, but subsequent remarks by Auriemma clarified that he felt the officials were not doing enough to stop rough play, and he didn't want to "put his players into any more physical danger by crossing midcourt".

[42] UConn's game against Notre Dame on 16 January didn't tipoff until 9 pm, but the arena opened at 7:30 in the morning.

The campus, shut down for winter break, opened a day earlier than usual to allow students to return in time to attend GameDay.

[43] Right now, if you took a poll of those award-voters who truly follow women's hoops, Charles likely would be the unanimous winner for national player of the year.

Rutgers was the last team to beat UConn in the regular season, winning at their home in 2008, but on this day, the results would not be close.

98–56, but the benchmark reached by Tina Charles, as she became only the sixth player in UConn history to score 2,000 points in her career.

8 in the country at the time of the game, but had already faced strong teams this season, and had beaten West Virginia by 30 points in the previous year.

[51] Before the game against St. John's, Tina Charles was inducted into Huskies of Honor, to reflect her position as one of the most significant figures in the history of the team.

[53] Connecticut would continue their winning streak against Syracuse four days later, when Maya Moore had a season high 38 points and a career-high 20 rebounds in an 87–66 victory.

[54] Connecticut played 11th ranked Georgetown with an opportunity to clinch the Big East regular season title.

[56] Geno Auriemma Chris Dailey Shea Ralph Marisa Moseley Roster Last update: 2013-08-23 XLC—Veterans Memorial Coliseum at XL Center e Exhibition ß Big East The Big East tournament started with first round action on Friday, 5 March 2010.

By virtue of being one of the top four seeds, UConn earned a double-bye, with their first game scheduled in the quarterfinals on Sunday.

[58] UConn defeated West Virginia, 60–32, to improve their winning streak to 72 games, and making their season record 33–0.

Kalana Greene's 15 points guided the Huskies to victory, and help her to earn the Most Outstanding Player award for the tournament.

The two teams last played each other in 1999, when Iowa State knocked number one seeded UConn out of the NCAA tournament.

Maya Moore outscored Iowa State in the first half, despite sitting more than ten minutes with two fouls.

The lead would grow to 50, at which time the starters all sat for the remainder of the game, and the final margin tightened.

The twelve points scored by UConn was the lowest first half total in the history of Connecticut basketball.