The 2009–10 EHF Champions League was the 50th edition of Europe's premier club handball tournament and the seventeenth edition under the current EHF Champions League format.

The final was played on 30 May 2010, at the Lanxess Arena, home ground of VfL Gummersbach and Kölner Haie, in Cologne, Germany.

[1] The draw for the group stage took place at the Liechtenstein Museum in Vienna on 24 June 2009.

Teams were divided into four pots, based on EHF coefficients.

Group 1 HC Vardar Skopje HC Dinamo Minsk Besiktas JK RK Budućnost Podgorica Group 2 STR Saporischschja A.C. PAOK SPE Strovolos Group 3 Fyllingen Handball A1 Bregenz RK Partizan Si&Si Group 4 Tatran Prešov Vive Targi Kielce FC Porto Vitalis Group 5 CB Ademar León TBV Lemgo Celje Kadetten Schaffhausen Group A Chekhovskiye Medvedi Montpellier HB SC Pick Szeged BM Valladolid HCM Constanța A.C. PAOK Group B MKB Veszprém Gorenje Chambéry Savoie Rhein-Neckar Löwen RK Bosna Sarajevo Vive Targi Kielce Group C BM Ciudad Real HC Croatia Zagreb HSV Hamburg FCK Handbold Alingsas HK Fyllingen Handball Group D THW Kiel KIF Kolding FC Barcelona Borges Ademar León ZMC Amicitia Zürich HC Vardar Skopje The Last 16 fixtures of the 2009–10 EHF Men's Champions League were drawn in the EHF Headquarters on 9 March 2010.