[3] Jason Clark came off the bench to score 13 points at Tulane[2] and a game-high and career-high 14 at Savannah State, a game in which he connected on four three-pointers.

They then traveled to Madison Square Garden to make Georgetown's first appearance in the Jimmy V Classic and face their first ranked opponent of the season, No.

Greg Monroe played an outstanding defensive game that contributed to Butler junior forward Matt Howard shooting only 1-for-9 from the field and scoring only nine points.

[8] Georgetown next went to Anaheim, California, to make its only appearance in the John R. Wooden Classic and face its second ranked opponent in a row, No.

Georgetown still led 60–40 with 6½ minutes to play, but the Huskies took advantage of a 23-point performance by senior forward Quincy Pondexter and 21 points – 15 of them in the second half – by Thomas to stage a late comeback try that included a 15–3 run.

Washington closed to 69–63 with 27 seconds remaining, but Chris Wright and Hollis Thompson hit key free throws that ensured the Hoyas a 74–66 victory that stretched their season-opening winning streak to eight.

[12][13] Meanwhile, reserve forward Nikita Mescheriakov, averaging only five minutes per game, announced on December 22 that he would leave Georgetown at the end of the semester in search of greater playing time;[14] he transferred to Wake Forest in January.

[15] Mescheriakov became the ninth player in five years to leave Georgetown before the end of his college eligibility: Jeff Green and DaJuan Summers both had left school after their junior year to enter the National Basketball Association draft, and Omar Wattad, Vernon Macklin, Jeremiah Rivers, Octavius Spann, Marc Egerson, and Josh Thornton all had transferred.

[16] Another win followed against DePaul, the Hoyas′ ninth victory in a row against the Blue Demons and DePaul's 21st straight loss in a Big East Conference game, with Georgetown shooting 57 percent from the field and four Hoyas – Chris Wright with 18 points, Austin Freeman with 17, Jason Clark with 13, and Greg Monroe with 10 – scoring in double figures.

Connecticut then went on a 6–0 run to take a 40–21 lead before Chris Wright connected on a two-point jumper with 45 seconds left until halftime – ending a 9½-minute stretch in which the Hoyas missed 11 consecutive shots from the field and saw their shooting effort for the game drop to 6-for-25 (24 percent) – to allow Georgetown to close to 40–23.

The game stayed tight, but Connecticut did not score a field goal during the final 3½ minutes, and a Julian Vaughn two-pointer put Georgetown ahead for good at 70–69 with 44 seconds left.

But Georgetown, playing tough defense that largely contained Pittsburgh's top-scoring players during the game, then went on a decisive 9–0 run during which Chris Wright put the Hoyas ahead for good at 59–56 with a three-pointer.

The Panthers suffered only their third loss in 13 games against ranked opponents at the Petersen Events Center, and Georgetown became the only team other than Louisville to defeat Pittsburgh twice there.

The Hoyas began the game with a 14–0 run over the first three minutes, hitting their first four three-pointers, but the Orange battled back to only a two-point deficit with 8:19 left in the first half time, and Syracuse had a 34–29 lead at halftime.

Shooting 77 percent from the floor in the first half, the Hoyas used an 18–3 run in which they held the Blue Devils without a field goal for nearly four minutes to jump out to what turned out to be a decisive 34–20 lead.

The Hoyas blew a first-half 13-point lead, their offense going cold in the second half, resulting in arguably the biggest win in the history of Bulls basketball.

2 Villanova – a team that had beaten them in January, had not yet lost a conference game during the season, and was riding an 11-game winning streak – on February 6.

Although about two feet (61 cm) of snow had fallen in Washington, D.C., that day, 10,387 fans – including Speaker of the United States House of Representatives Nancy Pelosi and former National Football League commissioner and Georgetown basketball player Paul Tagliabue – showed up at the Verizon Center for the game, some of the students in attendance having walked three miles (4.8 km) from the Georgetown campus.

7 and sporting records of 17–5 overall and 7–5 in the Big East, the Hoyas next went on a two-game road trip that yielded mixed results – a win at Providence[34] followed by an upset loss at Rutgers that was the Scarlet Knights′ first victory over a Top Ten team in seven years.

Although West Virginia shot only 43 percent from the field, the Mountaineers scored 24 points off 20 Georgetown turnovers and outscored the Hoyas 27–14 in free throws.

The Hoyas defense clamped down on the Bulls, holding them to 29.1 percent shooting from the field, a season low for South Florida.

Meanwhile, Jason Clark and Greg Monroe each scored 16 points and Chris Wright added 15 as Georgetown cruised to a 69–49 victory, the Hoyas′ first win in a postseason tournament since 2008.

The Hoyas scored on their first six field goal attempts and quickly pulled ahead to a 15–4 lead, but the Golden Eagles′ offense came alive and went on a 15–5 run that tied the game at 29–29.

After a timeout, West Virginia senior forward Da'Sean Butler, who had 20 points during the game, scored in the lane with 4.2 seconds left to give the Mountaineers a 60–58 lead.

Chris Wright drove the length of the court and missed a final shot at the buzzer, and West Virginia won its first Big East tournament championship.

Ohio cruised to a shocking 97–83 upset victory, the first time the Bobcats had won an NCAA tournament game since 1983,[52] and Georgetown's season came to a sudden and unexpected end.

[53] Monroe opted to leave the team after the season, foregoing his junior and senior years of college to enter the 2010 National Basketball Association draft; the Detroit Pistons selected him.

[54] After a first year in which he had scored only in the Lafayette game and taken only one shot and played only four minutes during the remainder of the season, reserve guard Stephan Stepka also left, transferring to James Madison.

The 2009–10 Hoyas played short-handed, with an understrength roster, shallow bench, and no seniors, and, like the 2008–09 team, their fortunes declined as the regular season wore on.

For the rest of John Thompson III's tenure as head coach, the Hoyas would never advance beyond the first weekend of the NCAA tournament.