The 2009–10 season was the 99th season in the history of Grenoble Foot 38 and the club's second consecutive season in the top flight of French football.

In addition to the domestic league, Grenoble participated in this season's editions of the Coupe de France and the Coupe de la Ligue.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Source: Competitions Source: Ligue 1